Monday, 16 November 2015

Emerging Insulin Drug and Delivery Technologies Market Analysis, Market Size, Share, Regional Outlook, Industry Trends, Competitive Strategies And Segment Forecasts, 2013 To 2019

Globally, emerging technologies in the insulin drug and delivery field have shown potential in the diabetes market, with enhanced glucose control, along with well-accepted newer delivery methods. Contemporary industries, market players and research institutes have begun to explore novel methods for diabetes control in adults, leading to a steady market growth for these technologies.
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Research and development spending, patent expiries, increasing competition and emerging technologies are expected to support the growth of this market. Technological advancements, new product launches, increased awareness and early detection of the disease have further influenced the market to develop in the foreseeable future.

The global market for insulin drug and delivery devices was estimated at USD 24.12 billion in 2012. Further the overall insulin drug and device market reached USD 25.72 billion by 2013 and is expected to grow at a CAGR of 9.6% from 2013 to 2019.

This research report provides comprehensive market statistics and forecast for key segments, and provides complete industry landscape including drivers, restraints, regulatory scenario, technology trends and future opportunities. The report also provides detailed competitive landscape with company market share analysis and in-depth profiles of key market participants. Key regional markets analyzed and reported in this study include:

  • North America
  • Europe
  • Asia Pacific
  • RoW

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Critical elements of the report include:
  • Industry dynamics
  • Market challenges and opportunities
  • Technology & regulatory trends
  • Market estimate and forecast
  • Regional trends
  • Competitive trends

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Why should you buy this report?

  1. This report provides comprehensive analysis of the market including Porter’s and SWOT analysis
  2. Complete identification and analysis of key industry dynamics including drivers, restraints, raw material trends and buyer behavior
  3. The study provides technology landscape and regulatory trends for building strategy
  4. Global and regional market estimates and forecast on volume and revenue basis for multiple market segments
  5. Detailed competitive landscape of the market, with profiles of key companies

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About Us:

Hexa Research is a market research and consulting organization, offering industry reports, custom research and consulting services to a host of key industries across the globe. We offer comprehensive business intelligence in the form of industry reports which help our clients obtain clarity about their business environment and enable them to undertake strategic growth initiatives.

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Ryan Shaw
Hexa Research
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Thursday, 12 November 2015

Global Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics Market Size, Regional Outlook, Application Analysis, Competitive Insights And Forecasts, 2014 To 2020

Market research report on Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics market by Hexa Research provides a clear picture about the worldwide development of the Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics industry and recent key trends based on detailed statistical analysis. This new report provides latest market data, including market estimate and forecast by application and product on a regional basis for historic years of 2012 and 2013 with forecast up to 2020. This report is an invaluable resource for industry executives looking for key market data in readily available and clearly presented graphs and tables.
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Major regional markets covered in this report include North America, Europe, Asia Pacific and Rest of the world. Additionally, the Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics market report includes comprehensive industry landscape, with market dynamics, drivers, restraints, opportunities and critical success factors. The Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics market report analyzes major companies dealing in this market and provides company market share analysis. The report also contains detailed profiles of key market players with product benchmarking and company revenue analysis.

The report firstly provides market segmentation, current market scenario, growth prospects and value chain analysis. Then the report deeply analyzes the Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics market conditions that include growth feasibility analysis, Porter's five force analysis, PESTEL Analysis and market driver impact analysis. The growth feasibility analysis points out key areas in this market that deserve the most attention from market participants.

Overall, it is a comprehensive research report on the Global Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics market; Hexa research is thankful to industry experts related to Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics market for their valuable feedback and opinion during research compilation process.
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Reasons to Buy This Report

  • Find out global Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics Market size, growth rate and forecast to 2020
  • Key drivers and restraints of global Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics Market
  • Key opportunities in the Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics Market
  • Detailed regional estimates and forecast by application (North America, Europe, Asia Pacific, and Row) of global Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics Market
  • Competitive landscape, with Idiopathic Thrombocytopenic Purpura (ITP) Therapeutics Market company market share and detailed profiles of key market players

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About Us:

Hexa Research is a market research and consulting organization, offering industry reports, custom research and consulting services to a host of key industries across the globe. We offer comprehensive business intelligence in the form of industry reports which help our clients obtain clarity about their business environment and enable them to undertake strategic growth initiatives.

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United States
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Catheters Market Size, Market Share, Application Analysis, Regional Outlook, Growth, Trends, Competitive Scenario And Forecasts, 2012 To 2020

Industry Insights

Catheters market is expected to grow over the forecast period owing to the increasing prevalence of cardiovascular diseases and growing demand for minimally invasive medical procedures. The other growth drivers of this market are growing incidences of lifestyle induced diseases such as obesity & diabetes, sophisticated healthcare infrastructure, increasing population and awareness.

These factors are expected to drive the market over the forecast period. For the purpose of conducting therapeutic and diagnostic treatment, flexible and hollow tubes are inserted into the body, which are referred as catheters. As per the recent report published by WHO, by 2030, 25 million people will die due to prevalence of cardiovascular disease. Cardiovascular disease includes hypertensive heart disease, stroke, ischemic heart disease (IHD), aortic aneurysms, cardiomyopathy, rheumatic heart disease (RHD), congenital heart disease, atrial fibrillation, peripheral artery disease (PAD) and endocarditis.
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Minimally invasive surgeries are now more preferred than normal surgeries, as it has many advantages attached to it, such as shorter duration of stay at hospital, shorter recovery duration, less risk of bleeding and infection, and scars length is short. Quick procedure duration and faster patient recovery time are two important factors towards the rising demand of medical procedures. Over the forecast period, growing demand of minimally invasive procedures in the emerging countries like China and India is expected to fuel the future growth of this market. Over the upcoming forecast period, catheter market is expected to grow at a CAGR of 9.7%. In 2013, the market was valued at $ 24,380.3 million.

Product Insights

Catheters market is segmented on the basis of types into urology, cardiovascular, neurovascular, intravenous and specialty catheters. Among these, cardiovascular catheters held the largest market share in 2013 due to high incidences of cardiovascular diseases, increasing patient awareness and availability of high unmet medical demand in this segment. In 2013, revenue share of this market was approximately 40.0%. Further, due to adaptation towards minimally invasive interventional cardiology procedures and introduction of newly developed product i.e. bio-absorbable stents, has increased demand of these catheters, and the market is expected to grow nearby to CAGR of 16% over the upcoming five years. Market penetration rate will significantly elevate, as bio-absorbable stents are at low re-stenosis rates.
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Bio-absorbable stents are used for removing blockage or expand the vessel by inserting a tube or device into the blood vessel. Advantage of bio-absorbable stents is that it can absorb or dissolved in the body after sometime of surgery, as compared to traditional stents. In terms of revenue, catheters are following stents, as it holds 10.0% market stake due to the increasing demand for angiography catheters. Heart related disorders such as blood vessel irregularities, congenital heart defects and atherosclerosis are diagnosed with the help of angiography catheters. A small incision is made in femoral artery, through which catheter is inserted and then moved to actual sire.

Regional Insights

Geographically, the catheters market is studied by segmenting the market into North America, Europe, Asia Pacific and RoW. North America is dominating the whole market due to high per capita healthcare expenditure, sophisticated healthcare infrastructure, rising disposable income, various government or NGO’s initiatives, and increasing geriatric population. In 2013, North America generated over 37% of revenue. The growing economies in Asia Pacific such as India and China region are expected to witness lucrative growth during the forecast period due to the rising healthcare expenditure, and awareness about the catheters. Asia Pacific region is expected to grow at a CAGR of 13.5% over the forecast period.

Competitive Insights

The major market players in the Catheters market are Abbott Laboratories, Boston Scientific Corporation, Arrow International, Coloplast, Medtronic Inc., and Johnson & Johnson.
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About Us:

Hexa Research is a market research and consulting organization, offering industry reports, custom research and consulting services to a host of key industries across the globe. We offer comprehensive business intelligence in the form of industry reports which help our clients obtain clarity about their business environment and enable them to undertake strategic growth initiatives.

Contact Us:


Ryan Shaw
Hexa Research
Felton Office Plaza
6265 Highway 9
Felton, California 95018
United States
Phone: +1-800-489-3075

Tuesday, 3 November 2015

Medical Imaging Systems Market Analysis, Market Size, Share, Regional Outlook, Industry Trends, Competitive Strategies And Segment Forecasts, 2012 To 2020

Industry Insights

Medical imaging systems market is expected to grow over the forecast period owing to the increasing prevalence of chronic diseases such as diabetes, cardiovascular diseases, and cancer. The other drivers of this market are growing geriatric population, high patient awareness and the introduction of PACS & advanced medical imaging systems. Globally, geriatric population base is more impressionable towards respiratory diseases, orthopedic and cardiovascular disease.

Chronic diseases especially pertaining to cardiovascular systems, respiratory and brain will drive the market over the forecast period. Chronic disease is that type of disease which exists for more than three months and its effects are shown after some period of time. As per the recent report published by WHO, it say that it is the leading cause of mortality globally. It says that as of 2013, nearly 45 million deaths occurred globally due to chronic diseases and among all deaths, its share is above 65%.
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Globally, medical imaging systems market as of 2013 was valued $ 25,710.5 million and over the forecast period i.e. upcoming five years, it will grow at a CAGR of over 6%. PACS stands for picture archiving and communication systems and it stores and transfer medical images, which obtained from medical imaging devices such as CT and X-ray. The market has a huge opportunity over the forecast period as due to increasing demand for computed and digital radiography systems and through introduction of mobile imaging systems.

Product Insights

Medical imaging systems market is segmented on the basis of product types into handheld X-ray devices, portable X-ray devices, ultrasound, CT, closed & open MRI, nuclear imaging, high slice, medium slice and low slice scanners. Among these, X-ray devices held the largest market share in 2013. Further, this market is classified into stationary, handheld and portable devices. Availability of a relatively higher application base coupled with increasing penetration rate in underdeveloped and emerging market is one of the major reasons for its entire market dominance.

The evolution of filmless X-ray systems, as it is environment friendly, increasing demand for back fitted and cost effective systems is expected to boost the market. At the fastest CAGR of 7%, SPECT and PET market will grow over the upcoming five years. Under non-invasive and minimally invasive interventional medical procedures, nuclear imaging in combo with CT and MRI scan systems has a huge opportunity over the forecast period.
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Technology Insights

Medical imaging systems market is segmented on the basis of technology into digital radiography, computed radiography system, 4D & 5D and X-ray systems include analog. Among these, computed radiography held the largest market share in 2013, as it is user friendly which cuts the costs associated in re-training of employees when healthcare system is shifted from analog to digital system. Digital radiography will grow at a CAGR of 5.8% over the forecast period as it is add on features like easy storage & transmission, faster image acquisition rates and cost effectiveness. 4D & 5D are expected to witness lucrative and highest growth rate over upcoming five years.

Regional Insights

Geographically, the medical imaging systems market is studied with respect to four regions such as North America, Europe, Asia Pacific and RoW. North America is dominating the whole market as it has high disposable income, strong R&D, favorable policies, and better healthcare infrastructure. Asia Pacific is expected to show a lucrative growth rate over the forecast period. The presence of high geriatric population and developing economy are the factors expected to drive the growth of medical imaging market in this region.

Competitive Insights

The major market players in the medical imaging systems market are, GE Healthcare, Shimadzu Corporation, Philips healthcare, Toshiba America Medical Systems, Siemens healthcare and Hitachi Medical Corporation.
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About Us:

Hexa Research is a market research and consulting organization, offering industry reports, custom research and consulting services to a host of key industries across the globe. We offer comprehensive business intelligence in the form of industry reports which help our clients obtain clarity about their business environment and enable them to undertake strategic growth initiatives.

Contact Us:


Ryan Shaw
Hexa Research
Felton Office Plaza
6265 Highway 9
Felton, California 95018
United States
Phone: +1-800-489-3075 FREE

Apheresis Equipment Market Analysis, Market Size, Share, Regional Outlook, Industry Trends, Competitive Strategies And Segment Forecasts, 2012 To 2020

Industry Insights

Apheresis equipment market is expected to grow over the forecast period owing to the increasing prevalence of hemophilia, sickle cell anemia, blood cancer and rising demand for blood products. The other growth drivers of this market are lifestyle induced diseases such as obesity & diabetes, sophisticated healthcare infrastructure, increasing geriatric population and awareness. These factors are expected to drive the market over the forecast period.

Apheresis is process in which blood passes through an apparatus and the components of the blood get separated. The targeted components are separated and remaining components are returned to the circulation. For this whole procedure medical technology and extracorporeal therapy are used. The components which are extracted from the blood units are leukocytes, plasma and platelets.
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With the help of therapeutic apheresis, the components which are contributing towards diseases are removed from the blood. Stem cell harvesting, leukopheresis, plateletpheresis and plasmapheresis are the few examples of the disease inducing blood components. Familial hypercholesterolemia or FH is one of the examples of genetic disorders. It is further characterization into bad cholesterol LDL on the basis of high cholesterol.

LDL-apheresis application is used for those patients who are not responding to regular medical treatment and patient suffering from rhabdomyolysis or breakdown of coronary heart disorder. Apheresis equipment is widely used for the blood with high in cholesterol. The other factor which is anticipated to drive the market over the forecast period are rising incidences of chronic diseases such as cancer and autoimmune diseases, favorable reimbursement policies, biopharmaceutical companies incresing demand for plasma, sophisticated healthcare infrastructure in developing economies, and increase in number of platelet donors.

Product Insights

Apheresis equipment market is segmented on the basis of product types into disposables, and devices. Among these, devices held the largest market share in 2013 in terms of revenue, as these devices prices are very high. Disposable medical devices usages rate is growing as it prevents infections such as bloodstream and it also slows down the incidence or cases rates of hospital acquired infections. Over the forecast period, apheresis equipment market is expected to grow at a faster rate. 

Application Insights

Apheresis equipment market is segmented on the basis of application into neurology, hematology, and renal diseases. Among these, neurology application held the largest market share in 2013, due to the rising plasma exchange coupled with majority of multiple sclerosis is increasing in U.S. Over the upcoming five years this application is expected to show fruitful CAGR. 
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Procedure Insights

Apheresis equipment market is segmented on the basis of procedure into erythrocytapheresis, photophereis, leukapheresis, plateletpheresis, LDL-apheresis, and plasmapheresis. Among these, plateletpheresis held the largest market share in 2013, owing to its uses in donor apheresis area, and its applicability is widespread. Photopheresis is the fastest growing procedure in 2013, as die to rising rate of graft versus host disease and scleroderma. Scleroderma mostly affects women four times more than man and it describes syndrome of dermatitis, enteritis, hepatitis and transplanted solid organs having a risk of chronic GVHD having unirradiated blood products, and lymphoid tissues. Over the forecast period plateletpheresis segment will witness lucrative growth rate. 

Technology Insights

Apheresis equipment market is segmented on the basis of technology into membrane centrifugation & filtration. Among these, centrifugation held the largest segment in 2013 owing to its use in apheresis of any of the blood components. Where-as, membrane technology is only restricted to plasma exchange. 

Regional Insights

Geographically, the Apheresis equipment market is studied with respect to four regions such as Asia Pacific, Europe, North America, and RoW. Among these, North America is dominating the whole market in 2013, as it has presence of technologically updated systems, strong research & development, various government initiatives & programs and high patient awareness levels in this region. The growing economies in Asia Pacific such as India and China region are expected to witness lucrative growth over the forecast period owing to the rising healthcare expenditure, and awareness about the hospital acquired infection. 

Competitive Insights

The major market players in the apheresis equipment market are Kawasumi Laboratories Inc., Hemacare Corporation, B. Braun Melsungen AG, Therakos Inc., Haemonetics Corp., Fenwal Inc., Terumo BCT Inc., and Asahi Kasei Kuraray Medical Co Ltd.
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About Us:

Hexa Research is a market research and consulting organization, offering industry reports, custom research and consulting services to a host of key industries across the globe. We offer comprehensive business intelligence in the form of industry reports which help our clients obtain clarity about their business environment and enable them to undertake strategic growth initiatives.

Contact Us:


Ryan Shaw
Hexa Research
Felton Office Plaza
6265 Highway 9
Felton, California 95018
United States
Phone: +1-800-489-3075

Monday, 2 November 2015

Sevoflurane, Isoflurane and Desflurane Market Size, Market Share, Application Analysis, Regional Outlook, Growth, Trends, Competitive Scenario And Forecasts, 2012 To 2020

Overview

The sevoflurane, isoflurane and desflurane market is expected to reach USD 1.5 billion by 2022 in comparison to USD 1.2 billion in 2014. These three chemicals are inhalation agents and have been used by anesthesiologists, nurse anesthetists, and anesthesiology assistants on a consistent basis. They are very strong and cost less, with minimum damage to the ozone layer.  
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Market Drivers


One of the primary factors, triggering expansion in the sevoflurane, isoflurane and desflurane market includes cardiovascular and respiratory diseases affecting the geriatric population. Rising cancer, orthopedic, spinal and gastro-intestinal cases have also furthered the market. Cataract surgery is a major contributor to the global market and will need a higher production of these chemicals.

Growing accidents and emergency cases also add income to the inhalation anesthesia market. Universal insurance coverage as well as constant improvements in medical infrastructure also ensure the development of the sevoflurane, isoflurane and desflurane market. These agents are administered to patients prior surgery, making the induction of general anesthesia much simpler.


A major factor hindering the market is the quantity of CO2 released in the environment, leading to global warming. Actually, only about 5 percent of the gases are consumed by patients. The rest are released into the atmosphere and make it unhealthy. The most practical solution for this problem is the anesthetic recycling of products used during the administration of general anesthesia.

Products Overview


Sevoflurane
Sevoflurane is one of the most commonly used volatile anesthetic agents. It is administered to babies and children. Sevoflurane is ideal for patients with asthma or sensitive air passages. But its side-effects include delirium and agitation. It can be given quickly without the use of intravenous instruments.


Sevoflurane would capture over 70% of the worldwide sevoflurane, isoflurane and desflurane market by 2022. The agent is expected to exceed USD 1 billion by the same year. It’s widely utilized for being low-priced and possessing therapeutic benefits.
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Isoflurane
Isoflurane is a halogen ether utilized frequently by veterinarians. It is administered intravenously, relaxes the muscles and reduces pain. Isoflurane has also been used for inducing sleepiness for long durations during surgery. It is expected to register a CAGR of about 10% by 2022.



Desflurane
Desflurane is a halogen ether used in general anesthesia. Its effectiveness is one-fifth of isoflurane. Desflurane cannot be administered orally and requires an electrically heated dispenser to distribute the vapor. It is mostly administered to bariatric patients and in cases of surgeries lasting for short durations.



Regional Overview
The United States has a large geriatric population. This has led the region of North America to occupy the biggest share in the worldwide inhalation anesthesia market in 2014. Surgical ambulatory and inpatient procedures are the driving factors of North America.


Asia Pacific will experience the fastest growth by 2022. This is owing to the rise of chronic diseases and need for better health infrastructure in the region. Medical tourism combined with insurance coverage will play a huge role in sustaining the growth of the sevoflurane, isoflurane and desflurane market.
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Key Players
The market is currently dominated by AbbVie and Baxter International. However, it can   expect strong competition from manufacturers like Lunan Pharmaceutical Group and Piramal Enterprises.
Piramal Enterprises currently has isoflurane and sevoflurane production underway. It will manufacture generic desflurane by 2016. AbbVie has sevoflurane and isoflurane under production. Baxter International is the only one that manufactures all the three products.

Anesthesia has some unhealthy effects. The recycling companies of Deltasorb Technologies and Anesthetic Gas Reclamation reprocess anesthesia containers and gases from hospital vents. Rising investments by the aforementioned players would also accelerate the sales of the sevoflurane, isoflurane and desflurane market.  
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About Us:

Hexa Research is a market research and consulting organization, offering industry reports, custom research and consulting services to a host of key industries across the globe. We offer comprehensive business intelligence in the form of industry reports which help our clients obtain clarity about their business environment and enable them to undertake strategic growth initiatives.

Contact Us:


Ryan Shaw
Hexa Research
Felton Office Plaza
6265 Highway 9
Felton, California 95018
United States
Phone: +1-800-489-3075

Audiology Devices Market Analysis, Market Size, Share, Regional Outlook, Industry Trends, Competitive Strategies And Segment Forecasts, 2012 To 2020

Industry Insights

Audiology devices market is expected to grow over the forecast period owing to the growing prevalence of hearing disorders and rising geriatric population base all over the world. The other growth drivers of this market include growing investments in R&D sector, sophisticated healthcare infrastructure and higher disposable income. Audiology devices are electronic devices that are used for treating and diagnosing hearing disorders.

Audiology devices are highly designed so that it can be used in the treatment of hearing impairment such as congenital hearing problem and nerve deafness. Hearing loss is classified into mixed, conductive and sensorineural hearing loss. Further, as per severity it is categorized into profound, moderate, severe and mild hearing loss.
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As we know that communication is one of the most important ways to communicate as it retain independence and improves relationships, so audiology devices are gaining importance globally. Along with the geriatric population, growing incidences of hearing impairment in youth is also one of the key drivers of this market. Healthcare industries, audiologists and service providers are the main users of these devices. Narrow pricing and development of products with high shelf life & efficiency is expected to restrain the market growth over the forecast period. The market has a huge opportunity over the forecast period due to the technological advancements such as wireless devices. Increasing demand for efficient & effective devices, acceptance of these devices especially by geriatric population and growing awareness.

Product Insights

Audiology devices market is segmented on the basis of product types into bone anchored hearing aids, cochlear implants, audiometers, hearing aids, tympanometers and otoscopes. Diagnostic devices comprises of otoscopes, audiometers and tympanometers. Technology aid devices comprises of analog hearing and digital hearing. Further, Hearing aids devices comprises of behind-the-ear (BTE) aids, receiver-in-the-ear (RITE) aids, in-the-ear (ITE) aids and canal hearing aids such as completely-in-canal (CIC), invisible-in canal (IIC) and in-the-canal hearing aid (ITC). Among these, cochlear implant held the largest market share in 2013, as 80% sentences are understood as compared to other devices only achieves 10%. Cochlear implant gives a clear sense of sound, as it overcomes damaged sensory hair cells. It is the best substitute for hearing but is does not cure deafness.
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Cochlear implant comprises of stimulator, receiver, transmitter, speech processor, and microphones. Different manufacturers produce different types of electrodes. Innovation in audiology devices improves the patient's ability to hear, operating time, complications, and reduced risk of infection. Over the forecast period audiology devices market is expected to boost due to increase in demand for complete-in-canal hearing aids and invisible-in-canal hearing aids. As cochlear implants and anchored devices are the recent innovations, so it is expected to grow at faster pace over the forecast period. Behind-the-ear (BTE) and in-the-ear (ITE) are two of the most popular among all audiology devices due to highly efficient for hearing impairment or deafness, easy to use, easy connectivity and high comfort.

Regional Insights

Geographically, the audiology devices market is studied by segmenting the market into North America, Europe, Asia Pacific and RoW. North America is dominating the whole market due to high per capita healthcare expenditure, sophisticated healthcare infrastructure, rising disposable income, various government or NGO’s initiatives and increasing geriatric population. Asia Pacific is expected to witness lucrative growth rate over the forecast period due to increasing population, government initiatives and growing economies.

Competitive Insights

The major market players in the audiology devices market are GN ReSound Group, William Demant Holdings A/S, Starkey Hearing Technologies, Sonova Holdings AG, Audioscan, Siemens Healthcare and Widex A/S, Cochlear Ltd., Audioscan, ReSound, Interacoustics, Advanced Bionics, Rayovac, Natus, MED-EL, Grason-Stadler, Duracell, Oticon, Sophono, Power One, MedRx, NHC/Amplifon, National Hearing Care, and Austar Hearing.
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About Us:

Hexa Research is a market research and consulting organization, offering industry reports, custom research and consulting services to a host of key industries across the globe. We offer comprehensive business intelligence in the form of industry reports which help our clients obtain clarity about their business environment and enable them to undertake strategic growth initiatives.

Contact Us:


Ryan Shaw
Hexa Research
Felton Office Plaza
6265 Highway 9
Felton, California 95018
United States
Phone: +1-800-489-3075